Mutational profile of CBF-AML. (A) Spectrum of recurrent mutations in 215 pediatric and adult patients with CBF-AML. ASXL1, ASXL2, and EZH2 mutations are mutually exclusive of each other as are mutations of members of the cohesin complex. These mutations were only detected in t(8;21) patients. (B) AML with inv(16) largely lack mutations of chromatin modifiers and cohesion complex members, which are common in t(8;21) AML and AML in general as reported by The Cancer Genome Atlas (TCGA) Research Network.9 *The TCGA data were derived by whole genome/exome sequencing and therefore are capable of detecting mutations of genes in each respective class not evaluated in this study. This figure has been adapted from Figure 1 in the article by Duployez et al that begins on page 2451.
