Figure 1
![Figure 1. Accumulation of monoallelic mutations in HLH-causing genes increases the risk to develop clinical manifestations of HLH. Control (black squares), Prf1−/− (open squares), Rab27a+/− Stx11+/− (AS, open gray circles), Rab27a+/− Prf1+/− (AP, gray squares), and Rab27a+/− Prf1+/− Stx11+/− mice (ASP, gray open squares) were infected with 200 PFU of LCMV-WE. (A) Survival, (B) body weight, and (C) body temperature are shown. Data (mean ± standard error of the mean [SEM]) are representative of 3 to 4 independent experiments with at least 3 mice in each group. *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/17/10.1182_blood-2015-12-688960/4/2113f1.jpeg?Expires=1735494915&Signature=wsQwAyhdqUyUR--3sAERyAEobbURsSdBGzLBEEiQ6v5JDaUPyE7tsxOAkMRz1PjYh~QFSa1gXLGWKTIZB6sQ3twcBkFwM9l9dAKhr2VPaWpgoJMDxgRL-IXruj4XOF0kYfpQfxR8C8ZeZ4mRUEORoToGENIkOMbg5Njt2~XRn2H8BroJtEvHBkh2bOprZVkfXezHdbCxW1WUXOMHTK7pH0q1Ieeuzx549NOqKbud5tnh2r27Z7-0zgRBYSnAVsOU~ydsZZ-ewDHVQ~b140I8GHV3tyu4Hthpm~2mLNTLbOYKVXJtkdBkv7W4YQ7uwN8S65aJnMZasVtD~4l8pB-7jw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Accumulation of monoallelic mutations in HLH-causing genes increases the risk to develop clinical manifestations of HLH. Control (black squares), Prf1−/− (open squares), Rab27a+/−Stx11+/− (AS, open gray circles), Rab27a+/−Prf1+/− (AP, gray squares), and Rab27a+/−Prf1+/−Stx11+/− mice (ASP, gray open squares) were infected with 200 PFU of LCMV-WE. (A) Survival, (B) body weight, and (C) body temperature are shown. Data (mean ± standard error of the mean [SEM]) are representative of 3 to 4 independent experiments with at least 3 mice in each group. *P < .05.
