Reversal of clinical signs of sclerodermatous cGVHD with KD025 treatment. BALB/c mice were transplanted with B10.D2 BM and T cells and given either 150 mg/kg KD025 or 0.4% methylcellulose vehicle control starting after initial signs of cGVHD and harvested on day 51 following transplantation. (A) Clinical skin scores, (B) skin pathology, (C) highlights of pathology (*epidermal hyperplasia and ^∨keratosis; bar, 500 μM), (D) clinical GVHD scores, and (E) percent weight loss. Whole spleens were assessed for Stat3 phosphorylation normalized to actin and expression of IRF4 (F and quantified in G and H, respectively). *P < .05; **P < .01. Error bars represent SEM; data from 2 separate experiments with n = 8 per group.