Figure 1
![Figure 1. Normal ABL1 kinase plays a tumor suppressor role in BCR-ABL1–induced leukemogenesis. BCR-ABL1 Abl1−/− [−/−], BCR-ABL1 Abl1+/+ [+/+], and BCR-ABL1 Abl1−/− leukemia cells reconstituted with YFP-ABL1 [−/−(+)] were inoculated IV into NOD/SCID mice. Kaplan-Meier survival curve of mice injected with (A) 103 freshly transfected cells [(−/−) and (+/+): n = 8] and (B) 103 [(+/+): n = 6, (−/−) and (−/−)+: n = 12] or (C) 105 [(−/−): n = 13, (+/+) and (−/−)+: n = 12] 5-week-old tissue-cultured cells; n = number of mice per group.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/17/10.1182_blood-2015-11-681171/4/2131f1.jpeg?Expires=1735825823&Signature=qMEOFI0F3MQBqb2jrb7jeaQHNutnDnPmbAmS~Y6dvP9Kk84l9FpJVr7NR7oULX22CYASRWVoLs~hRqUggNGA5UyBPW~JCwrYZqUdtU-7ZW~7FmdGj0vnDLKHqlNaMFkfBKIEcXV~48PgjHB6aa65Hbbvaj~bKd194V2GeSOPqdxt-ZGuoYOQx85z9oDCZ2ficIqKcjR7Vaj4vcDeFffmiVCO1gGbXwIuLcaE98x697QKxqn3MdmOruX0r9vnCKmh4CGZ9OyMPZP5gnIzMfUY5ug9-uvxWwUHpPJq-ZltIjG16ICPDCpTl-mIJYdkDWzGHT0O6UrTHwpVdtxYDJJ0zQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Normal ABL1 kinase plays a tumor suppressor role in BCR-ABL1–induced leukemogenesis. BCR-ABL1 Abl1−/− [−/−], BCR-ABL1 Abl1+/+ [+/+], and BCR-ABL1 Abl1−/− leukemia cells reconstituted with YFP-ABL1 [−/−(+)] were inoculated IV into NOD/SCID mice. Kaplan-Meier survival curve of mice injected with (A) 103 freshly transfected cells [(−/−) and (+/+): n = 8] and (B) 103 [(+/+): n = 6, (−/−) and (−/−)+: n = 12] or (C) 105 [(−/−): n = 13, (+/+) and (−/−)+: n = 12] 5-week-old tissue-cultured cells; n = number of mice per group.
