Role of the GPCR Gβ subunit isoforms in chemokine-induced signaling mechanisms leading to LFA-1 activation. Chemokine ligand binding induces the dissociation of the Gα and Gβγ subunits followed by a macromolecular complex formation between the Gβ subunits, Rac1, and Plcβ2/3. The complex initiates the release of IP3 followed by calcium signal, resulting in LFA-1 integrin activation. There might be an alternative signaling pathway (dashed line), in which Rac1 induces LFA-1 activation independently from Plcβ2/3. The figure has been adapted from Figure 6 in the article by Block et al that begins on page 314.
