Figure 4
![Figure 4. HCLS1g496a/D166N germ line variant characterizes familial WM cases. (A) Distribution of the variant among familial (n = 50) and nonfamilial (n = 196) cases. (B) Genomic structure: location of the HCLS1 locus is shown by a red line; the centromere is indicated by red triangles. Gene structure is also shown (National Center for Biotechnology Information Reference [RefSeq] number, NM_005335). The exon is indicated by a blue box. The variant localizes in exon 7. (C) Secondary structures for HCLS1 were predicted by Interpro (http://www.ebi.ac.uk/interpro). Mutation positions and amino acid changes are indicated in red.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/127/21/10.1182_blood-2015-11-680199/4/2598f4.jpeg?Expires=1735508451&Signature=GkDoU7Psbq~nVdRmQU3vBh17pubhs2V-kFuxPRyntTsicCguwTlTCWlUQPcV5x9hCQeAZo-Dk2bm~FKtnet67ISzDoYncwmyaKMVbtUZj4~4PAkddqAsPpF4mgLGlvT7Wumz~memwZ-1mrANyVuZSmp6g2AKS13~MzXHvAl2Nbl3eGXfUgtBBTMgXrXGQiGzZy8Ey3Nd-DroXlUbnfLr2D5sWtsP9KWmPA90qqIw0AyXmfmYdopTuOH-QYlsE59A-pmzIhboHY0MnBHGAC7pj8gQTuOszh~05~w-Bl~FhDLy07H8kqDWDrMZJCAdbNtSRiQJ0R9OuMdHFAAtLdhgcw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
HCLS1g496a/D166N germ line variant characterizes familial WM cases. (A) Distribution of the variant among familial (n = 50) and nonfamilial (n = 196) cases. (B) Genomic structure: location of the HCLS1 locus is shown by a red line; the centromere is indicated by red triangles. Gene structure is also shown (National Center for Biotechnology Information Reference [RefSeq] number, NM_005335). The exon is indicated by a blue box. The variant localizes in exon 7. (C) Secondary structures for HCLS1 were predicted by Interpro (http://www.ebi.ac.uk/interpro). Mutation positions and amino acid changes are indicated in red.
