Mutational landscape of CEBPA^bi AML. (A) Mutation profile of CEBPA^bi AML. Samples are grouped together according to the type of CEBPA mutations: typical CEBPA^bi, atypical GEP+ CEBPA^bi, and atypical GEP− CEBPA^bi, illustrated by shades of gray from light to dark. Each column represents a patient sample. (B-C) Primary structures of STAT5B (B) and CSF3R (C) proteins with corresponding positions of mutations in CEBPA^bi and non-CEBPA^bi (other) AML. (D) Expression of ELANE and CD117 in GEP+ CEBPA^bi compared with normal sorted granulocyte populations from peripheral blood (n = 5, red) and normal marrow precursors (n = 4, orange). FNIII, fibronectin type III; Granulo, granulocytes; Ig, immunoglobulin; Inter, intermediate; Meta, metamyelocytes; Mut, mutated; Myelo, myelocytes; NPM1, nucleophosmin 1; Promyelo, promyelocytes.