Figure 2
Figure 2. Reversal of hemoglobin switching to induce therapeutic levels of HbF. Reversal of hemoglobin switching can be accomplished through autologous bone marrow transplantation of genome-edited CD34+ HSPCs. The gray region indicates the hypothesized levels of HbF required for clinical benefit.

Reversal of hemoglobin switching to induce therapeutic levels of HbF. Reversal of hemoglobin switching can be accomplished through autologous bone marrow transplantation of genome-edited CD34+ HSPCs. The gray region indicates the hypothesized levels of HbF required for clinical benefit.

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