The CEBPA TAD exhibits a diverse combination of active enhancers in different CEBPA⁺ tissues. ChIP-seq for H3K27ac conducted in terminally differentiated neutrophils and monocytes (in-house) was compared with publicly available ChIP-seq H3K27ac (www.roadmapepigenomics.org/). Superimposed H3K27ac (top; green) ChIP-seq profiles from 14 different CEBPA⁺ tissue types shows 14 potential enhancers situated within the CEBPA TAD at 5′ (−9, −14, −25, −47, −56, −64 kb) and at 3′ (+9, +15, +21, +29, +34, +42, +50, +55 kb). Each individual CEBPA⁺ tissue type (middle; blue) shows a different combinatorial set of active enhancers. CEBPA⁻ tissue types (bottom; red) do not exhibit H3K27ac at the locus, except at CEBPG. An intergenic 8-kb hotspot (red) located within the 21-kb contact domain (gray), contains 2 potential enhancers (+34 kb and +42 kb) that are H3K27ac enriched in neutrophils and monocytes only. G.I, gastrointestinal.