FXI peptide complex structures. (A) Cartoon diagram showing only the apple 2 domain in white, with laminin LP2 peptide shown as sticks in purple. Electrostatic and hydrogen bonding interactions are shown as lavender dotted lines. Residues interacting with the peptide are shown as sticks in green. (B) Charged surface representation of the apple 2 domain (blue is positive, red is negative) bound to the P39 peptide (orange) shown as sticks. (C) Schematic diagram illustrating the P39 peptide (purple) bound to the apple 2 domain, calculated using LIGPLOT software, with major and minor pockets indicated. (D) Cartoon diagram of the apple 2 domain in white, with bound HK peptide in blue shown as sticks. (E) Schematic diagram illustrating HK peptide (purple) bound to the apple 2 domain, calculated using LIGPLOT. (F) Superposition of the FXI-P39 and FXI-HKP peptide apple 2 domain structures. The apple 2 domain is shown as a cartoon in white for the FXI-P39 structure, and the P39 and HKP peptides are shown as sticks in orange and purple, respectively.