The RHOA hotspot mutations reported so far in various tumor subtypes.^1-9  The disease categories, mutations, and biochemical properties linked to increased and decreased RHOA activity are indicated by red and blue color, respectively. Image of 1A2B¹⁰  created with PyMOL (Schrödinger, LLC). GDP, guanosine diphosphate; GEF, guanine nucleotide exchange factor; Treg, T-regulatory cell.