Genomic data of 549 genes from 101 Sézary tumors identifies candidate driver genes. Heat map showing all genes (y-axis) and all tumors (x-axis) (left); pathways identified as frequently perturbed are aligned below the main panel (bottom). The color code represents the percentage of mutationally perturbed genes in each tumor sample for each pathway. Candidate driver genes showing high frequencies of SNVs (top right), frequently deleted genes (middle right), and frequently amplified genes (bottom right) are subsetted from the main panel.