Gas6 deficiency also protects mice against B-cell lymphoma. (A) Lymph node volume was measured in the same mouse prior to (D0) and after (D6) the injection of Eμ-myc B-cell lymphoma. Lymphoma significantly increased lymph node size in WT and Gas6^−/− mice after 6 days. (B) Eμ-myc B-cell lymphoma significantly increased thrombus cross-sectional area in the IVC of WT mice but not in the IVC of Gas6^−/− mice. *P < .05 comparing WT vs WT + Eμ-myc; **P < .05 comparing WT + Eμ-myc vs Gas6^−/− + Eμ-myc, and Gas6^−/− vs Gas6^−/− + Eμ-myc. D0, day 0; D6, day 6.