Gene expression in WT and Gas6^−/− endothelial cells exposed to M27 cancer cells. (A) 311 genes (circle A) were either up- or downregulated in WT endothelial cells upon exposure to M27 cancer cells. Twelve of those genes were not Gas6 dependent because they were differentially expressed in response to cancer cells in WT and Gas6^−/− endothelial cells (circles A and B). Forty-nine genes were unrelated to cancer because they were differentially expressed in the absence of M27 cancer cells (circle C). That left 250 genes differentially expressed in WT endothelial cells cultured with M27 cancer cells that were Gas6 dependent. (B) 5 of those 250 genes (circle D) were common to 46 genes (circle E) differentially expressed when M27 cancer cells were cultured with WT vs Gas6^−/− endothelial cells. (C) Identity of the 5 genes of interest with relevant fold changes and P values. Ptges was most significantly (i) upregulated in WT endothelial cells exposed to M27 cancer cells and most significantly (ii) downregulated in Gas6^−/− endothelial cells cultured with M27 cancer cells.