Long-term stress-induced thrombopoiesis contributes to the aggravation of atherosclerosis in ApoE^−/− mice. (A) Representative aortas from ApoE^−/− mice subjected to noise or exhaustive exercise stress for 8 weeks. (B) Quantification of the lesion size in the whole aorta. Each data point represents a value from a single mouse; n = 6. (C) Immunofluorescence staining of platelets with the CD41 antibody in the atherosclerotic lesions in the right carotid artery. (D) Quantification of fluorescence intensity of CD41 in the atherosclerotic lesions in the right carotid artery. (E) Distributions of MKs in the BM in the mice. (F) Quantification of MKs in the BM. *P < .05, **P < .01, vs control.