Genome-wide mapping of direct target genes of Mef2c identified by ChIP-seq analysis in pro-B cells. (A) Mef2c bound regions in 4 gene loci identified by peak calling. Known binding sites of E2a, Runx1, and regions with H3K4me3 determined in pro-B cells and binding sites of Pax5 and Ikaros identified in pre-B cells are shown.^2,5,38,39  The UCSC Genome Browser was used to visualize binding patterns. Below, exon-intron structures of genes and a scale bar in kilobases are shown. Transcript direction is indicated by an arrow. The results of 2 ChIP-seq analyses are shown (Mef2c-I and Mef2c-II). (B) Frequency of Mef2c peaks with the indicated distance to the nearest TSS is shown. (C) Consensus sequences within 150 bp of the Mef2c-peak summits identified by de novo–motif discovery. The frequency of the motif around Mef2c peaks (n = 500) and the calculated E values are given. (D) The frequency of known E2a, Pax5, Ikaros, or Runx1 peaks^2,5,38,39  within the indicated distance from Mef2c-peak summits is shown.