Serum chemistries in FVII-G96E dogs expressing cFVII. Serum glutamyl pyruvic transaminase (SGPT) (A), serum creatine phosphokinase (CPK) (B), serum glutamyl oxaloacetic transaminase (SGOT) (C), alkaline phosphatase (AP) (D), total bilirubin (E), and γ glutamyl transpeptidase (GGTP) (F) levels were monitored throughout the study, before and after AAV administration (black arrow, day 0). A shaded box indicates the normal range of values for each marker. The following symbols are used for the FVII-G96E dogs: closed squares (N24, 4.95E13 vg/kg), open circles (N22, 2E12 vg/kg), closed circles (N25, 6E11 vg/kg), and closed rhombi (Otis, 2E11 vg/kg).