Transplant-related mortality (TRM) in relation to gene variant number identified. Shown is TRM in patients with 0 to 2 gene variants detected compared with those with ≥3 gene variants detected. TRM among study patients was calculated by using the Kaplan-Meier method. The 2 groups were found to significantly differ by using the log-rank test (P = .02). The TRM at 1 year and 3 years after HSCT was much higher in patients with ≥3 gene variants (57% at 1 year and 71% at 3 years) compared with the patients with 0 to 2 variants (21% at 1 year and 24% at 3 years).