Genes and pathways that are recurrently affected by genetic lesions in NMZL. (A) Genes (n = 41) that were recurrently affected by mutations and/or focal copy number aberrations in ≥3 of 35 of NMZL. The bar graph represents the frequency of molecular lesions in each gene. (B) Molecularly deregulated pathways in NMZL. In the heatmap, rows correspond to genes and columns represent individual patients. Color coding is based on gene alteration status (white, wild-type; green, mutated; blue, loss; red, gain). The bar graph represents the frequency of molecular lesions in each gene. The overall frequency of genetic lesions in each pathway is indicated.