PTPRD mutations are enriched in NMZL among mature B-cell tumors. (A) The heatmap represents the frequency of mutations in the top genes that are affected in at least 15% cases of NMZL and/or SMZL. P values from the comparison of the mutation frequency in NMZL vs SMZL by Bonferroni corrected Fisher exact test. (B). Prevalence of nonsynonymous PTPRD mutations among mature B-cell tumors (NMZL, nodal marginal zone lymphoma, data from this study; SMZL, splenic marginal zone lymphoma, data from this study and others^5-7,9 ; DLBCL, diffuse large B-cell lymphoma, data from various studies^22,37,45,47 ; BL, Burkitt lymphoma, data from various studies^40,41 ; CLL, chronic lymphocytic leukemia, data from various studies^38,39,44,49 ; MCL, mantle cell lymphoma, data from Beà et al⁴³ ; PMBCL, primary mediastinal large B-cell lymphoma, data from Gunawardana et al¹⁵ ; FL, follicular lymphoma, data from various studies^37,48 ; MM, multiple myeloma, data from Chapman et al³⁶ ; WM, Waldenström macroglobulinemia, data from various studies^42,46 ; EMZL, extranodal marginal zone lymphoma, data from this study; PCNSL primary central nervous system lymphoma, data from various studies^52-55 ).