Mutated genes involved in TCR costimulation or intracellular signaling. Positive and inhibitory interactions are depicted as solid green and red arrows, respectively. The protein symbols of mutated genes appear inside colored ovals depending on the frequency of mutation (yellow, <5%; red, >5%). Those of wild-type (WT) genes appear in blue ovals, and not-sequenced genes are in gray. PI3K, phosphatidylinositol 3-kinase. See Figure 2 in the article by Vallois et al that begins on page 1490.