circRNA is a new member of the platelet transcriptome. circRNA species primarily use canonical splice sites and may be amplified by reverse transcriptase polymerase chain reaction using pairs of oligonucleotides (F+R) designed to be divergent on the linear messenger RNA (mRNA) species, but convergent on circRNAs. The existence of lariats in platelets remains to be confirmed. E, exon; F, forward; I, intron; m⁷G, 7-methylguanylate cap; R, reverse. Professional illustration by Somersault18:24.