LIN28B overexpression in JMML. (A) Diagonal plot showing significantly downregulated (blue) and upregulated (red) genes (adjusted P < .05) in patients compared with healthy donors. (B) Log2 expression of LIN28B in the discovery cohort, measured on Agilent microarray. LIN28B expression is shown in 7 healthy donors, 19 LIN28B-low, and 25 LIN28B-high patients. (C) Log2 expression of LIN28B in the validation cohort, measured on Affymetrix microarray. LIN28B expression is shown in 9 healthy donors, 21 LIN28B-low patients, and 17 LIN28B-high patients.