LIN28B overexpression is correlated with high HbF levels and the absence of monosomy 7. (A) HbF percentage (not corrected for age) in patients with low and high LIN28B expression. (B) HbF percentage in relation to age at diagnosis and karyotype. Patients with monosomy 7 are indicated in red. (C) Overview of LIN28B expression, HbF level, age at diagnosis, monosomy 7, and mutational status in 82 JMML patients. (D) Circos plot representing the relationships among LIN28B expression, HbF level, age at diagnosis, monosomy 7, and RAS mutational status in 69 JMML patients with complete data available. Quadr. neg., quadruple negative.