Impact of GEP70 risk and bi-allelic events on overall survival after relapse. Nonsilent mutations and deletions affecting 10 selected tumor-suppressor genes with a potential impact on MM pathogenesis^17,20  were identified using whole-exome sequencing and high-resolution arrays, respectively. (A) The overall survival after relapse according to the classical GEP70 risk status determined at relapse is shown. (B) Impact of bi-allelic events in at least one of the 10 selected tumor suppressor genes on outcome. (C-D) Overall survival after relapse according to the type of aberration affecting FAM46C and TP53, respectively. We assumed that the bi-allelic deletion affecting TP53 in patient 23 was still present at relapse (no array data available) and included this patient. Survival rates after relapse were estimated using the Kaplan-Meier method. The log-rank test was used to perform group comparisons.