Relapse-free and treatment-free survival after vemurafenib in relapsed/refractory HCL. Kaplan-Meier curves displaying the survival free (A) from relapse and (B) from a subsequent antileukemic treatment in the HCL-PG01 phase-2 Italian trial at a median follow-up of 23 months after the last vemurafenib dose. Relapse was defined as the reappearance of 1 or more cytopenias (neutrophils, <1.5 × 109/L; platelets, <100 × 109/L; or hemoglobin, <11 g/dL). Time to relapse (A) was longer (by log-rank test) in patients who achieved a complete remission vs a partial remission. This difference was less evident regarding time to next treatment (B), as various patients relapsing after a partial remission developed mild cytopenias (eg, ∼1 N × 109/L or ∼80 platelets × 109/L) which remained relatively stable for some time and did not immediately trigger a subsequent treatment. Reprinted from Tiacci et al63 with permission.
