Distribution of T lymphocytes and NK cells. Distribution of CD4, CD8, and TCRγδ T lymphocytes and CD56^dim and CD56^bright NK cells in PB samples from heathy individuals aged >60 years (n = 10) and high-risk patients with SMM (n = 31) studied at baseline and after 3 and 9 cycles of induction therapy with LenDex as assessed by multiparameter flow cytometry. (A) Absolute counts (cells per microliter). (B) Ratio of CD56^dim to CD56^bright NK cells and of CD8 to CD4 T lymphocytes. (C) Distribution of antigen-maturation related subsets within total CD4 (upper row) and CD8 (lower row) T lymphocytes. (D) Percentage of Tregs among nucleated PB cells. (E) Percentage of total DCs among nucleated PB cells (left) and distribution of DC subsets (right), including plasmacytoid, BDCA-1–positive and –negative DCs, and tissue macrophages. In (A), bars represent median values; vertical lines represent the upper bound of the 95% confidence intervals. In (D) and (E), notched boxes represent 25th and 75th percentile values; the line in the middle corresponds to the median value, and the vertical lines correspond to both the 10th and 90th percentiles.