Gene expression changes of key regulatory pathways in MCL (Granta cells) exposed to pevonedistat. (A) Granta cells were exposed to pevonedistat for 24 hours (250 and 500 nM) or 48 hours (250 nM) and then placed on Illumina HumanHT-12v4 whole-genome expression microarray. A total of 737 genes were found to be differentially expressed in all conditions tested. (B) Hierarchical clustering of expression profiles of the 737 genes differentially expressed in all the cell line exposed to pevonedistat. In the clustering heat map, red indicates upregulation, whereas green indicates downregulation. (C) List of the cellular pathways of genes affected by pevonedistat exposure (500 nM for 24 hours shown).