Rare POT1, ACD, and TERF2IP mutations in CLL families. Black-filled symbols indicate CLL cases, other cancers are indicated by a red-filled symbol, and an unfilled symbol indicates an individual with no known cancer. These symbols have a central dot to indicate cases that were exome sequenced. A central blue dot denotes a shelterin gene mutation carrier; a peach dot denotes a WT individual. A line through a symbol indicates that an individual is deceased. Age of diagnosis (in years) is listed for CLL cases. Splice acceptor variants are numbered relative to POT1 transcript NM_015450 and ACD transcript NM_001082486. NHL, non-Hodgkin lymphoma.