The number of cells with HSC cell surface markers is not restored after 15 months without MOZ. (A) Experimental design. Mice were treated with poly(I:C) and then left undisturbed for 15 months; bone marrow stem cell populations and stage of the cell cycle were then quantitated in 3 Moz^fl/fl;Mx1-cre and 3 control Moz^fl/fl mice. (B) Flow cytometry plots showing analyses of the LSK-CD34^–FLT3^– and the LSK-CD48^–CD150⁺ populations in Moz^fl/fl and Moz^fl/fl;Mx1-cre bone marrow 15 months after poly(I:C) treatment. Note that these are similar to those shown in Figure 2. (C-D) Quantification of stem cell markers by flow cytometry of Moz^fl/fl and Moz^fl/fl;Mx1-cre bone marrow cells. Note the reduction in typical LSK-CD34^–FLT3^– and LSK-CD48^–CD150⁺ populations. (E) Cell cycle analysis of stem/progenitor populations. Note the reduction in the number of cells in G₀. Data are presented as the mean ± SEM.