Recommendation for anticoagulant therapy in hemophilia patients with atrial fibrillation. Compared with our previous flowchart,²  notice the following adaptations: baseline FVIII/FIX changed from 30% to 20%; CHADS₂ changed to CHA₂DS₂VASC; DOAC added; in patients with factor levels 1% to 20%, the threshold for the CHA₂DS₂VASC is raised to 4 and the option of catheter ablation is added.