Inhibition of the hedgehog pathway reduces the proliferation of T-ALL cell lines. (A-B) Pharmacological inhibition of the hedgehog pathway by treatment with SMO inhibitor GDC-0449 (A) or GLI1 inhibitor GANT61 (B) reduces the proliferation of T-ALL cell lines. Cell lines in which the proliferation is significantly inhibited are shown in red. (C-D) Response of the same T-ALL cell lines to the inhibitor treatment as measured by effects on GLI1 expression. Red color corresponds to the cell lines with significant inhibitory effects on proliferation as shown in panels A and B.