FBXO11 deletion in mice leads to lymphoproliferative disease. (A) Incidence of florid follicular hyperplasia (FFH), lymphoproliferative disease (LPD), and DLBCL in 17- to 18-month-old FBXO11^+/+-Cγ1cre^tg/+ (WT), FBXO11^fl/+-Cγ1cre^tg/+ (HET), and FBXO11^fl/fl-Cγ1cre^tg/+ (KO) mice. N = number of analyzed mice; *P < .05 (1-way ANOVA). (B) Lymph node sections representative of no pathology (normal), FFH, LPD, and DLBCL were stained with hematoxilin/eosin (H&E), B220 (blue) and CD3 (brown), or BCL6 as indicated. Images were acquired using 10× and (for the insets) 20× objectives leading to an overall magnification of ×100 and ×200, respectively.