The cost-effectiveness of any intervention can be classified into 1 of 4 areas. If the treatment strategy is more effective and costs less than the comparison, it falls into the right lower quadrant and is referred to as the dominant strategy, indicating it should be the preferred strategy. When the strategy under consideration is less effective and costs more than the comparison, it falls into the upper left quadrant and is considered to be dominated by the other strategy. Interventions that fall into this quadrant should not be chosen when given the choice. The other 2 quadrants indicate tradeoffs between cost and effectiveness of the intervention and need to be considered in the context of other policy and clinical practice guideline decisions.