The miR-125b/BIK/MTP18 axis controls monocyte mitochondrial metabolism. The ER BH3-only protein BIK and the mitochondrial fission process 1 protein (ie, MTP18) are 2 novel cellular targets of miR-125b. An increase of miR-125b expression through TLR4 engagement affects mitochondrial respiration and dynamics through BIK and MTP18 silencing, respectively. Mitochondrial fusion induction and decrease of mitochondrial respiration promote apoptosis of monocytes. The figure was produced using Servier Medical Art.