Both models show a strikingly similar positive correlation between CD49d and markers associated with antigen presentation and activation. (A) PBMCs were introduced into the circulating model system for 48 hours, and the MFI values for both the migrated and circulating CLL cells recorded. There is a positive correlation between the expression of CD49d and CD80 (Ai), CD86 (Aii), HLA-DR (Aiii), CD69 (Aiv), and CD38 (Av). (B) MFI data from matched LN and PB-CLL cells from 11 patients were analyzed for correlation. There was a positive correlation between expression of CD49d and CD80 (Ai), CD86 (Aii), HLA-DR (Aiii), CD69 (Aiv), and CD38 (Av). Each solid box represents the CD80, CD86, HLA-DR, CD69 or CD38 MFI plotted against the CD49 MFI for an individual patient sample.