CD19-CAR–modified T_SCM exhibit enhanced metabolic fitness. (A) ECAR of CD19-CAR–modified standard and T_SCM-enriched products from a representative healthy donor (HD) under basal culture conditions and in response to the indicated molecules. Data are shown as mean values ± SEM. (B) Glycolytic response by CD19-CAR–modified standard and T_SCM-enriched products of 6 HDs following glucose administration. ECAR values are shown after subtraction of basal ECAR measurements (*P < .05; Wilcoxon matched-pairs signed rank test). (C) OCR of CD19-CAR–modified standard and T_SCM-enriched products from a representative HD under basal culture conditions and in response to the indicated molecules. Data are shown as mean values ± SEM. (D) SRC (maximal OCR − basal OCR) of CD19-CAR–modified standard and T_SCM-enriched products of 6 HD. 2-DG, 2-Deoxyglucose.