sIgM levels or signaling and FISH lesions in CLL. CLL samples were investigated for sIgM expression (MFI) and signaling capacity (iCa²⁺ %) by flow cytometry. The CLL patient cohort were divided by FISH lesions according to Dӧhner hierarchical model. Association between (A) sIgM levels, or (B) signaling capacity with FISH lesions was investigated. Association between sIgM levels (C,E) and signaling capacity (D,F) with FISH lesions was also investigated in the U-CLL and M-CLL patient cohort, respectively. Horizontal bars indicate mean values. Statistical analysis were done by comparing isolated del13q vs each other individual FISH category using the Mann-Whitney test (2-tailed, 95% CI). P values are represented only for statistically significant differences.