American Society of Hematology

Figure 3

$Figure 3. Gene inactivation of ALK-5 or TGF-βRII in myeloid cells enhances intraluminal neutrophil adhesion and extravasation in cremaster venules. IVM of the inflamed cremaster of ALK-5lox/lox, TGFβRIIlox/lox, ALK-5LysMKO, and TGF-βRIILysMKO mice 4 hours after intrascrotal injection of 50 ng IL-1β. (A) Rolling flux fraction, (B) leukocyte adhesion, and (C) leukocyte extravasation in postcapillary venules. Data are shown as mean ± SEM. *P < .05; **P < .01; ***P < .001.$

Gene inactivation of ALK-5 or TGF-βRII in myeloid cells enhances intraluminal neutrophil adhesion and extravasation in cremaster venules. IVM of the inflamed cremaster of ALK-5^lox/lox, TGFβRII^lox/lox, ALK-5^LysMKO, and TGF-βRII^LysMKO mice 4 hours after intrascrotal injection of 50 ng IL-1β. (A) Rolling flux fraction, (B) leukocyte adhesion, and (C) leukocyte extravasation in postcapillary venules. Data are shown as mean ± SEM. *P < .05; **P < .01; ***P < .001.

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