Figure 3
Figure 3. Phenotypes of mice expressing the JAK2-Ex12 transgene. MxCre;Ex12 double transgenic mice were compared with MxCre;V617F mice (ie, mice expressing the JAK2-V617F transgene) and WT control mice. (A) Time course of blood counts (average ± SEM) before pIpC injection (0) and every 4 weeks after pIpC injection is shown. The group sizes were: MxCre;Ex12 (n = 15), MxCre;V617F (n = 10), and WT (n = 13). (B) Survival of mice is shown. (C) Picture of a spleen from a MxCre;Ex12 and a WT mouse 24 weeks after pIpC. (D) Spleen weight of MxCre;Ex12 (n = 10), MxCre;V617F (n = 12), and WT mice (n = 4) 24 weeks after pIpC. (E) Time course of blood counts in C57BL/6 lethally irradiated recipient mice transplanted with BM cells from MxCre;Ex12, MxCre;V617F, or WT donor mice (n = 8 mice per group). One-way ANOVA with subsequent Bonferroni post-test was used. *P < .05. MCV, mean corpuscular volume; RBC, red blood cell.

Phenotypes of mice expressing the JAK2-Ex12 transgene.MxCre;Ex12 double transgenic mice were compared with MxCre;V617F mice (ie, mice expressing the JAK2-V617F transgene) and WT control mice. (A) Time course of blood counts (average ± SEM) before pIpC injection (0) and every 4 weeks after pIpC injection is shown. The group sizes were: MxCre;Ex12 (n = 15), MxCre;V617F (n = 10), and WT (n = 13). (B) Survival of mice is shown. (C) Picture of a spleen from a MxCre;Ex12 and a WT mouse 24 weeks after pIpC. (D) Spleen weight of MxCre;Ex12 (n = 10), MxCre;V617F (n = 12), and WT mice (n = 4) 24 weeks after pIpC. (E) Time course of blood counts in C57BL/6 lethally irradiated recipient mice transplanted with BM cells from MxCre;Ex12, MxCre;V617F, or WT donor mice (n = 8 mice per group). One-way ANOVA with subsequent Bonferroni post-test was used. *P < .05. MCV, mean corpuscular volume; RBC, red blood cell.

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