CC-115 inhibits proliferation of healthy T cells. (A-B) PBMCs from healthy donors were incubated with 0.001 to 10 μM CC-115, CC-214, CC-292, idelalisib, or NU7441 for 48 hours. Specific apoptosis was analyzed in (A) CD19⁺ B cells or (B) CD3⁺ T cells. Results are shown as mean ± SEM, n = 3, not significant (1-way ANOVA). (C) PBMCs from healthy donors were stimulated with αCD3/αCD28 in the presence or absence of 1 μM CC-115, CC-214, CC-292, idelalisib, or NU7441 for 72 hours (n = 3). CFSE was measured by FACS in CD8⁺ T or CD4⁺ T cells. Bars represent mean ± SEM. *P < .05, **P < .01, ***P < .001 (1-way ANOVA).