Changes in bone marrow iron distribution associated with TfR1 haploinsufficiency. (A) Bone marrow nonheme iron concentration in WT, TfR1^+/−, th3/+, and double-heterozygote mice (n = 4-6 mice per group). Bone marrow CD45 negative cells (erythroid precursor enriched population) in WT and TfR1^+/− mice (n = 4-6 mice per group) (B) as well as th3/+ and double-heterozygote mice (n = 4-6 mice per group) (C). *P < .05; **P < .01 vs WT mice; †P < .05; ††P < .01 vs th3/+ mice.