Model of lymphovenous clot dynamics and lymph flow. (A) Lymphovenous clots block retrograde blood flow and increasing lymphatic pressures until the clots are resolved and a bolus of lymph fluid is infused into the bloodstream. (B) Lymphovenous clot formation at several lymphovenous junctions preventing retrograde or forward flow, but allowing flow in the remaining active vessels. (C) Lymphovenous clot formation occurs when the lymphovenous junction is in a blood environment, and the clot is resolved as lymph fluid envelops the clot, mediating fibrinolysis and forward lymph flow. P_L, lymphatic pressure.