Sin3B-regulated transcriptional networks in HSCs. (A) Heat map depicting significantly dysregulated genes in Sin3B^CKO HSCs compared with control (FDR <0.1; fold change >1.5). (B) GSEA of control and Sin3B^CKO HSCs. FWER, family wise error rate; NES, normalized enrichment score. (C) ChEA of significantly dysregulated genes in Sin3B^CKO HSCs. (D) FLAG immunoprecipitation (IP) was performed in HPC-7 cells infected with MSCV-IRES-GFP (EV) or MSCV-Sin3B FLAG-IRES-GFP (Sin3B FLAG). Representative immunoblot analysis is shown.