Proposed model of PTP1BΔ6 action in cHL. (A) Structural models of PTP1B_WT (top) and PTP1BΔ6 (bottom) generated by the SEQALSV (Sequence Alignment-based Sequence Variability) and AS2TS (amino acid sequence into tertiary structure) online software tools. (B) Schematic representation of the potential mode of action of FLAG-PTP1BΔ6. FLAG-PTP1BΔ6 binds and diminishes the negative effects of PTP1B_WT. In addition, PTP1BΔ6 forms complexes with yet unknown interaction partners (labeled as X). ER, endoplasmic reticulum; RTK, receptor tyrosine kinase.