CMV-specific T-cell responses. (A) IE1-exon4- and IE2-exon5-specific T-cell responses. UPN 24 (top plot) and UPN 9 (lower plot) represent longitudinal profiles, showing expansion of the 3 CMV antigens expressed by Triplex. Two injections of Triplex were administered on days 0 and 28. (B) CD8⁺ pp65_495-503-specific T-cell levels. Box plots cover central 50% of observations, and the central bars show median. Whiskers extend to at most 1.5 times box length, and individual observations are shown with colored circles. Red circles indicate subjects from DL1; green indicates subjects from DL2, and blue indicates subjects from DL3. The black line shows the fitted means on a square-root scale from a piecewise linear GEE model, with a change in slope at day 42 and no DL distinction.