Model of the induction of a VEGFA autocrine loop by miR-125b. Overexpression of miR-125b inhibits translation of TET2, which in turn, through unclear mechanisms, results in increased VEGFA expression. VEGFA activates VEGFR2 on AML cells, resulting in increased survival and cellular proliferation.

Model of the induction of a VEGFA autocrine loop by miR-125b. Overexpression of miR-125b inhibits translation of TET2, which in turn, through unclear mechanisms, results in increased VEGFA expression. VEGFA activates VEGFR2 on AML cells, resulting in increased survival and cellular proliferation.

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