Landscape of somatic variants in 100 CML patients in serial samples. (A) At the time of initial diagnosis and (B) at the time of follow-up. Bar plots above each table indicate the number of variants each patient carried; bar plots on the left indicate the number of patients with variant in each gene. Intensities of heatmap cells indicate the VAFs of each somatic variant. Pie charts below the first 3 subplots indicate the portion of patients from each response group with mutations at the relevant stage. Columns (patients) are first sorted by their patient subgroup (responsive, resistant, and progressed), then by the mutation burden in all stages combined within their subgroup. Rows are sorted by cohort occurrence frequency in the diagnosis and follow-up samples combined. Row and column order is the same for all subfigures.