Mutation dynamics of somatic variants sorted and grouped using unsupervised hierarchical clustering. Rows are the gene names of all nonsilent variants found in the cohort (sorted by the clustering algorithm). Columns are the sample time points: T-cell, diagnosis, and follow-up (fixed temporal order). Color intensity indicates the row-normalized VAF. Major pattern groups are highlighted and labeled. The dot plot on the right represents the raw VAFs of the variants within each pattern group. Cells on the left indicate mutation presence in Catalogue of Somatic Mutations in Cancer (COSMIC) and Clinvar databases.