BCR-ABL transcript level at follow-up compared with changes in VAF.BCR-ABL level indicated on a log10 percentage scale for both subplots. Each circle in the left bee swarm plot represents a variant. Filled circles indicate TKI treatment failure in the patient that had that variant; empty circles indicate successful response. The right bee swarm plot shows the BCR-ABL transcript reduction level for patients without extra mutations. Each dot indicates an individual patient. The boxes on the far right indicate the number of patients within each decade of TKI response colored by pattern (patients with both pattern 2 and pattern 3 mutations are labeled here as pattern 2).